Analysis Tools
immune system
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• less sensitive to anti-IgM induced proliferation compared to wild-type controls but more responsive than mutant mice hemizygous for the transgene
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• in most mice the percentage of peritoneal B220+CD5+ cells is decreased compared to wild-type controls but increased compared to mutant mice not carrying the transgene
• however, some mice had frequencies of B1 cells near the normal range
• the frequency and number of splenic B cells are similar to wild-type controls
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• basal serum IgG3 levels are decreased compared to wild-type controls but increased compared to mutant mice not carrying the transgene
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• serum levels of IgM following TNP-Ficoll treatment are reduced compared to wild-type controls
• basal serum IgM levels are decreased compared to wild-type controls but increased compared to mutant mice not carrying the transgene
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hematopoietic system
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• less sensitive to anti-IgM induced proliferation compared to wild-type controls but more responsive than mutant mice hemizygous for the transgene
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• in most mice the percentage of peritoneal B220+CD5+ cells is decreased compared to wild-type controls but increased compared to mutant mice not carrying the transgene
• however, some mice had frequencies of B1 cells near the normal range
• the frequency and number of splenic B cells are similar to wild-type controls
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• basal serum IgG3 levels are decreased compared to wild-type controls but increased compared to mutant mice not carrying the transgene
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• serum levels of IgM following TNP-Ficoll treatment are reduced compared to wild-type controls
• basal serum IgM levels are decreased compared to wild-type controls but increased compared to mutant mice not carrying the transgene
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cellular
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• less sensitive to anti-IgM induced proliferation compared to wild-type controls but more responsive than mutant mice hemizygous for the transgene
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