About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3836396
Allelic
Composition		 Aicdatm1(cre)Mnz/Aicda+
Ightm3Mnz/Igh+
Myctm39Mnz/Myc+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicdatm1(cre)Mnz mutation (1 available); any Aicda mutation (58 available)
Ightm3Mnz mutation (1 available); any Igh mutation (41 available)
Myctm39Mnz mutation (1 available); any Myc mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
spontaneous chromosome breakage ( J:145691 )
• B cells within in Peyer's Patches or splenic B cells stimulated in vitro can have chromosomal translocations involving chromosomes 12 and 15
• the chromosome fusions occur precisely at the two loxP sites that exist in the Igh and Myc mutant alleles

immune system
abnormal B cell physiology ( J:145691 )
• B cells within in Peyer's Patches or splenic B cells stimulated in vitro can have chromosomal translocations involving chromosomes 12 and 15
• the chromosome fusions occur precisely at the two loxP sites that exist in the Igh and Myc mutant alleles

hematopoietic system
abnormal B cell physiology ( J:145691 )
• B cells within in Peyer's Patches or splenic B cells stimulated in vitro can have chromosomal translocations involving chromosomes 12 and 15
• the chromosome fusions occur precisely at the two loxP sites that exist in the Igh and Myc mutant alleles

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory