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Phenotypes Associated with This Genotype
Genotype
MGI:3836254
Allelic
Composition
Apoetm1Unc/Apoetm1Unc
Csf1op/Csf1op
Genetic
Background
involves: 129P2/OlaHsd * C3HeB/Fe * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (34 available); any Apoe mutation (163 available)
Csf1op mutation (1 available); any Csf1 mutation (48 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• mice are almost entirely free of fatty lesions in the aortic root compared to the 75% of atherosclerotic lesions in mice homozygote null for just the Apoe gene

homeostasis/metabolism
• total cholesterol levels are extremely high with a mean of 1056 mg/dl compared to 112 mg/dl for controls or 379 mg/dl mice for Apoe null mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory