Phenotypes Associated with This Genotype

Genotype
MGI:3836064

• Allelic Composition: jt^Ectr/jt^Ectr
• Genetic Background: involves: Swiss albino

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

limbs/digits/tail

abnormal digit morphology ( J:5005 )

• most commonly occurs on both hind feet but other foot combinations and all feet are sometimes involved

• Background Sensitivity: syndactylism is seen in 100% of offpsring on Swiss albino background but only 94% of hybrids with C57BL/6 show effects

syndactyly ( J:5005 )

• Background Sensitivity: two or three digits on one or more feet show varying degrees of fusion

abnormal digit development ( J:5005 )

abnormal embryonic autopod plate morphology ( J:5005 )

• incipient syndactylism is noted at E11.5 as a loss of postaxial tissue and slight decrease in tisse in the preaxial region

• by E13 reduction of footplate tissue is primarily postaxial, allowing the blastemata of digits 2,3, and 4 to develop close together