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Phenotypes Associated with This Genotype
Genotype
MGI:3835562
Allelic
Composition		 Erbb3tm2Cbm/Erbb3tm3Cbm
Erbb4tm1Fej/Erbb4tm1Fej
Cnptm1(cre)Kan/?
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnptm1(cre)Kan mutation (0 available); any Cnp mutation (26 available)
Erbb3tm2Cbm mutation (0 available); any Erbb3 mutation (47 available)
Erbb3tm3Cbm mutation (0 available); any Erbb3 mutation (47 available)
Erbb4tm1Fej mutation (1 available); any Erbb4 mutation (87 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:145464 )
• develop to term but die in the second post natal week

nervous system
nervous system phenotype ( J:145464 )
N
• central nervous system myelination is normal up to 11 days of age (optic nerve and corpus callosum)
abnormal myelination ( J:145464 )
• severely defective myelination in the peripheral nervous system

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory