Phenotypes Associated with This Genotype

Genotype
MGI:3835121

• Allelic Composition: Tg(B2M)55Hpl/?; Tg(CD8aCD8b)57Scr/?; Tg(HLA-B)22Hpl/?
• Genetic Background: involves: C57BL/6 * C57BL/LiA * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal cytotoxic T cell physiology ( J:127813 )

• infection with measles virus (MV) generates a large cytotoxic T cell population that can target human cells presenting MV antigens in the context of HLA-B27

• these HLA-B27-restricted CTLs have high affinity for MV antigens with half maximal CTL-mediated lysis of target cells occurring at low (3x10 M^-8) peptide concentrations

• these CTLs fail to generate a cytotoxic response against target cells with HLA-A2 haplotype

hematopoietic system

abnormal cytotoxic T cell physiology ( J:127813 )

• infection with measles virus (MV) generates a large cytotoxic T cell population that can target human cells presenting MV antigens in the context of HLA-B27

• these HLA-B27-restricted CTLs have high affinity for MV antigens with half maximal CTL-mediated lysis of target cells occurring at low (3x10 M^-8) peptide concentrations

• these CTLs fail to generate a cytotoxic response against target cells with HLA-A2 haplotype