Phenotypes Associated with This Genotype

Genotype
MGI:3835054

• Allelic Composition: Tg(LCK-NFKBIA)5Dwb/?
• Genetic Background: involves: BALB/c * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T-helper 1 physiology ( J:145531 )

• the decreased delayed type hypersensitivity response to antigen rechallenge and the decreased IFN-gamma secretion by T cells isolated from the draining lymph nodes to these rechallenged areas demonstrate a defective Th1 response

• defective class switching of antigen-specific immunoglobulin to IgG2a gives further evidence of a defective Th1-response

decreased susceptibility to type I hypersensitivity reaction ( J:145531 )

• antigen rechallenge in the lung leads to slightly less periarterial inflammation than in controls

• there is significant attenuation of airway hyperresponsiveness in these mice upon antigen rechallenge in the lung

• the number of cells isolated from BAL fluid in these aerosol rechallenged mice is one-third of controls

• the level of antigen-specific IgG2a in aerosol sensitized mice is markedly reduced

decreased susceptibility to type IV hypersensitivity reaction ( J:145531 )

• antigenic challenge after prior sensitization leads to 4-fold less swelling in the footpads compared to controls

decreased interferon-gamma secretion ( J:145531 )

• T cells isolated from the draining lymph nodes of mice rechallenged with antigen produce significantly less IFN-gamma than controls

hematopoietic system

abnormal T-helper 1 physiology ( J:145531 )

• the decreased delayed type hypersensitivity response to antigen rechallenge and the decreased IFN-gamma secretion by T cells isolated from the draining lymph nodes to these rechallenged areas demonstrate a defective Th1 response

• defective class switching of antigen-specific immunoglobulin to IgG2a gives further evidence of a defective Th1-response