Tg(LCK-NFKBIA)5Dwb
Transgene Detail

Summary

• Symbol: Tg(LCK-NFKBIA)5Dwb
• Name: transgene insertion 5, Dean W Ballard
• MGI ID: MGI:3056807
• Synonyms: IkappaBalpha(deltaN), IkappaNalphadeltaN-Tg, LCK
• Transgene: Tg(LCK-NFKBIA)5Dwb Location: unknown
• Alliance: Tg(LCK-NFKBIA)5Dwb page

Transgene origin

• Strain of Origin: C57BL/6 x DBA/2

Transgene description

• Transgene Type: Transgenic (Dominant negative, Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(LCK-NFKBIA)5Dwb expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  NFKBIA (4792)

  Nfkbia

  (MGI:104741)

• Mutation details: An amino acid-truncated human NFKBIA gene (coding for amino acids 37-317) fused to a FLAG epitope was placed under the control of a human LCK promoter. The protein encoded by this transgene lacks sequences required for signal-dependent degradation and functions as a constitutive repressor of multiple NK-kappaB pathways. Transgene expression was readily detected in the thymus and spleen as determined by immunoblot analysis. (J:93003)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:93003 Boothby MR, et al., Perturbation of the T lymphocyte lineage in transgenic mice expressing a constitutive repressor of nuclear factor (NF)-kappaB. J Exp Med. 1997 Jun 2;185(11):1897-907
• All: 18 reference(s)