Mouse Genome Informatics
cx
    Tg(KRT5-tTA)1216Glk/0
Tg(tetO-LMNA*G608G,-EGFP)VF1-07Maer/0

involves: FVB/N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• median survival is 14 weeks for mice withdrawn from doxycycline at 21 days and 7 weeks for those withdrawn at P0
• median survival can be increased from 7 weeks to 29 by providing mice with soft pellets on the cage floor

craniofacial
• following doxycycline withdrawal at birth, mice exhibit increased impaction of food or bedding material with acute inflammation to overt necrosis of the pulp, accumulation of cellulose in the pulp, and spread of inflammation into the periodontal ligament and surrounding bony structure unlike in wild-type mice
• following doxycycline withdrawal at birth, mice exhibit changes in the lower incisors and surrounding tissue unlike in wild-type mice

digestive/alimentary system
• following doxycycline withdrawal, mice exhibit hypoplasia in the stomach unlike in wild-type mice

growth/size/body
• following doxycycline withdrawal at birth, mice exhibit increased impaction of food or bedding material with acute inflammation to overt necrosis of the pulp, accumulation of cellulose in the pulp, and spread of inflammation into the periodontal ligament and surrounding bony structure unlike in wild-type mice
• following doxycycline withdrawal at birth, mice exhibit changes in the lower incisors and surrounding tissue unlike in wild-type mice
• at 7 weeks of age in mice withdrawn from doxycycline at birth

endocrine/exocrine glands
• six weeks after withdrawal of doxycycline, sebaceous glands exhibit irregular maturation of sebocytes unlike in wild-type mice
• six weeks after withdrawal of doxycycline, sebaceous glands appear enlarged and displaced
• six weeks after withdrawal of doxycycline, sebaceous glands exhibit hyperplasia unlike in wild-type mice
• 17 weeks after doxycycline withdrawal, sebaceous glands appear hypoplastic

immune system
• six weeks after withdrawal of doxycycline, inflammatory cells infiltrate the dermis unlike in wild-type mice

integument
• six weeks after withdrawal of doxycycline, sebaceous glands exhibit irregular maturation of sebocytes unlike in wild-type mice
• six weeks after withdrawal of doxycycline, sebaceous glands appear enlarged and displaced
• six weeks after withdrawal of doxycycline, sebaceous glands exhibit hyperplasia unlike in wild-type mice
• 17 weeks after doxycycline withdrawal, sebaceous glands appear hypoplastic
• six weeks after withdrawal of doxycycline, inflammatory cells infiltrate the dermis unlike in wild-type mice
• following doxycycline withdrawal, mice have thin coats
• however, hair follicle number is normal
• six weeks after withdrawal of doxycycline
• absent 17 weeks after withdrawal of doxycycline
• six weeks after withdrawal of doxycycline, inflammatory cells infiltrate the dermis unlike in wild-type mice
• 17 weeks after doxycycline withdrawal, the dermis exhibits fibrosis unlike in wild-type mice
• six weeks after withdrawal of doxycycline
• six weeks after withdrawal of doxycycline, mice exhibit hypergranulosis unlike wild-type mice
• six weeks after withdrawal of doxycycline, mice exhibit slight to moderate hyperplasia of the interfollicular epidermis unlike in wild-type mice
• after withdrawal of doxycycline, some areas exhibit severe hyperplasia unlike in wild-type mice
• six weeks after withdrawal of doxycycline, mice exhibit skin lesions of varying severity unlike in wild-type mice
• 17 weeks after doxycycline withdrawal, the dermis exhibits fibrosis unlike in wild-type mice

Mouse Models of Human Disease
OMIM IDRef(s)
Hutchinson-Gilford Progeria Syndrome; HGPS 176670 J:145312