Phenotypes Associated with This Genotype

Genotype
MGI:3834581

• Allelic Composition: Tlr4^lps-del/Tlr4^lps-del
• Genetic Background: C57BL/10ScN

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

rectal hemorrhage ( J:37271 )

• rectal bleeding after 7 days of dextran sodium sulfate treatment is reduced relative to controls

immune system

increased spleen weight ( J:37271 )

• spleen weight elevated with dextran sodium sulfate treatment relative to controls

respiratory system

enlarged lung ( J:114985 )

• significantly increased lung volume at 3 months of age in contrast to normal body weights through 12 months

abnormal pulmonary alveolar duct morphology ( J:114985 )

• enlarged air spaces distal to the terminal bronchioles

abnormal pulmonary alveolus morphology ( J:114985 )

• destruction of normal alveolar structures

skeleton

increased bone mineral content ( J:118467 )

• greater mineral content at 20-24 weeks

increased bone mass ( J:118467 )

• larger bones at 20-24 weeks of age

adipose tissue

decreased percent body fat/body weight ( J:118467 )

• 70% less body fat

vision/eye

abnormal retina rod bipolar cell morphology ( J:141070 )

• increased differentiation at around 13 days of age

• growth factor treatment enhances proliferation

abnormal retina progenitor cell morphology ( J:141070 )

• more proliferating cells in the retina at 6 days of age

• neuronal differentiation of precursors

• FGF-2 injection is required for a similar effect after 15 days of age

abnormal retina layer morphology ( J:141070 )

abnormal retina rod cell morphology ( J:141070 )

• increased differentiation of rod photoreceptors at around 13 days of age

• growth factor treatment enhances proliferation

abnormal retina pigment epithelium morphology ( J:141070 )

• increased number of proliferating cells in the retinal pigment cell layer at 6 days of age

nervous system

abnormal retina rod bipolar cell morphology ( J:141070 )

• increased differentiation at around 13 days of age

• growth factor treatment enhances proliferation

abnormal retina rod cell morphology ( J:141070 )

• increased differentiation of rod photoreceptors at around 13 days of age

• growth factor treatment enhances proliferation

pigmentation

abnormal retina pigment epithelium morphology ( J:141070 )

• increased number of proliferating cells in the retinal pigment cell layer at 6 days of age

hematopoietic system

increased spleen weight ( J:37271 )

• spleen weight elevated with dextran sodium sulfate treatment relative to controls

cardiovascular system

rectal hemorrhage ( J:37271 )

• rectal bleeding after 7 days of dextran sodium sulfate treatment is reduced relative to controls

growth/size/body

enlarged lung ( J:114985 )

• significantly increased lung volume at 3 months of age in contrast to normal body weights through 12 months

increased spleen weight ( J:37271 )

• spleen weight elevated with dextran sodium sulfate treatment relative to controls