About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3833619
Allelic
Composition		 Cdk6tm1Phin/Cdk6+
Tg(Lck-Akt1*E40K)E-3Pnt/0
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk6tm1Phin mutation (0 available); any Cdk6 mutation (39 available)
Tg(Lck-Akt1*E40K)E-3Pnt mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased tumor-free survival time ( J:144975 )
• most mice develop tumors by 22 weeks of age and die prematurely

neoplasm
increased T cell derived lymphoma incidence ( J:144975 )
• most mice develop tumors by 22 weeks of age and die prematurely

endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:144975 )
• most mice develop tumors by 22 weeks of age and die prematurely

immune system
increased T cell derived lymphoma incidence ( J:144975 )
• most mice develop tumors by 22 weeks of age and die prematurely

hematopoietic system
increased T cell derived lymphoma incidence ( J:144975 )
• most mice develop tumors by 22 weeks of age and die prematurely

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
01/13/2026
MGI 6.24 		The Jackson Laboratory