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Phenotypes Associated with This Genotype
Genotype
MGI:3833385
Allelic
Composition
Tg(Thy1-MAPT*K369I)K3Gotz/0
Genetic
Background
B6.Cg-Tg(Thy1-MAPT*K369I)K3Gotz
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice exhibit a strong cataleptic response to lower doses of the dopamine antagonist haloperidol compared to wild-type mice
• at 4 months, mice exhibit a lack of preference for a novel object compared to wild-type mice indicating impaired working memory
• mice exhibit postural instability as indicated by repeated slipping while crossing a narrow beam unlike wild-type mice
• at 4 weeks of age
• beginning at 4 weeks of age and becoming severe by 8 weeks of age
• mice exhibit reduced motor coordination on a challenging beam compared to wild-type mice
• mice exhibit postural instability as indicated by repeated slipping while crossing a narrow beam unlike wild-type mice
• motor coordination of old mice is not improved with L-dopa treatment
• however, motor coordination of young mice is improved with L-dopa treatment
• at 4 weeks of age, mice exhibit repeated and prolonged resting phases in an open field compared to in wild-type mice
• at 2 months, mice exhibit reduced locomotor activity and rearing in an open field compared to wild-type mice
• at 4 weeks of age
• by 38% at 4 weeks of age

nervous system
N
• despite muscular atrophy, no overt neurodegeneration is detected
• at 5 months, mice develop Bielschowsky silver+ intraneuronal inclusions unlike in wild-type mice
• age-dependent beginning at 12 months of age in the substantia nigra
• at 2 months, a few axonal swellings are detected unlike in wild-type mice
• spheroids are detected at 5 months and become larger and more numerous by 10 months unlike in wild-type mice
• at 3 months, anterograde transport of TH in the substantia nigra pars compacta neurons is impaired
• axonal transport is selectively impaired in the nigrostriatal system
• anterograde axonal transport of APP- and TH-containing vesicles and mitochondria is impaired
• anterograde transport in the sciatic nerve is impaired
• however, retrograde transport and transport of non-APP- and TH-containing vesicles and mitochondria are normal

muscle
• muscular atrophy begins at 4 weeks of age
• mice exhibit amyotrophy unlike wild-type mice
• however, no motor neuron degeneration is evident

growth/size/body
• female and male mice are lighter than wild-type mice by 30% and 27%, respectively

homeostasis/metabolism
• at 6 weeks, basal dopamine levels in the brain are decreased 15% compared to in wild-type mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
frontotemporal dementia DOID:9255 OMIM:600274
J:143439


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory