Tg(Thy1-MAPT*K369I)K3Gotz
Transgene Detail

Summary

• Symbol: Tg(Thy1-MAPT*K369I)K3Gotz
• Name: transgene insertion K3, Jurgen Gotz
• MGI ID: MGI:3833383
• Synonyms: K3
• Transgene: Tg(Thy1-MAPT*K369I)K3Gotz Location: unknown
• Alliance: Tg(Thy1-MAPT*K369I)K3Gotz page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F2

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Thy1-MAPT*K369I)K3Gotz expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MAPT (4137)

  Mapt	(MGI:97180)

• Mutation details: The promoter was used to drive neuron-specific expression of a mutated human cDNA lacking exon 3, containing four microtubule binding domains, and nucleotide substitutions that result in an amino acid substitution of isoleucine for lysine at position 369 (K369). One line was created (K3). (J:143439)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:143439 Ittner LM, et al., Parkinsonism and impaired axonal transport in a mouse model of frontotemporal dementia. Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15997-6002
• All: 8 reference(s)