Analysis Tools
immune system
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• there is about a doubling in the number of T cells found in the peritoneum
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• myelopoiesis is greatly enhanced in these mice
• there is a significant increase in the number of colonies generated by bone marrow cells or splenocytes in response to in vitro culturing with GM-CSF, M-CSF, or IL-3
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• there is about a doubling in the number of T cells found in the peritoneum
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• B cells express lower levels of CD21 and higher levels of CD23 on the cell surface compared to controls
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• profound reduction in transitional stage-2 B cells
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• about a five-fold reduction in follicular B cells
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• profound reduction in marginal zone B cells
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• spleen cellularity is reduced by more than half due to B cell lymphopenia
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• significant expression of MHCII complexes by circulating B cells suggest these B cells are in an activated state
• B cells have enhanced calcium flux upon activation
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• auto-antibodies of the IgA, IgG IgM classes develop as the mice age
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• mice develop anti-DS DNA IgG antibodies as they age with high levels detectable in all mice by 20 weeks of age
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• all mice have immunoglobulin complex deposition in the kidney by 8 weeks of age
• 83% of mice also have C3 complement deposition in the kidney
• severe glomerulonephritis occurs in these mice by one year of age
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renal/urinary system
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• all mice have immunoglobulin complex deposition in the kidney by 8 weeks of age
• 83% of mice also have C3 complement deposition in the kidney
• severe glomerulonephritis occurs in these mice by one year of age
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• immunoglobulin complex deposition in the kidney by 8 weeks of age
• 83% of mice also have C3 complement deposition in the kidney
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digestive/alimentary system
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• there is about a doubling in the number of T cells found in the peritoneum
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hematopoietic system
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• myelopoiesis is greatly enhanced in these mice
• there is a significant increase in the number of colonies generated by bone marrow cells or splenocytes in response to in vitro culturing with GM-CSF, M-CSF, or IL-3
|
|
• there is about a doubling in the number of T cells found in the peritoneum
|
|
• B cells express lower levels of CD21 and higher levels of CD23 on the cell surface compared to controls
|
|
• profound reduction in transitional stage-2 B cells
|
|
• about a five-fold reduction in follicular B cells
|
|
• profound reduction in marginal zone B cells
|
|
• spleen cellularity is reduced by more than half due to B cell lymphopenia
|
|
• significant expression of MHCII complexes by circulating B cells suggest these B cells are in an activated state
• B cells have enhanced calcium flux upon activation
|
