Phenotypes Associated with This Genotype

Genotype
MGI:3832542

• Allelic Composition: Rad50^tm1Jpt/Rad50^tm3Jpt; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

decreased hepatocyte proliferation ( J:144766 )

• following partial hepatectomy, proliferation of pIpC-treated hepatocyte is decreased compared to in wild-type mice due to accumulation of DNA damage

• however, a subset of hepatocytes resolve their DNA damage and divide

abnormal hepatocyte morphology ( J:144766 )

• while liver regeneration following partial hepatectomy is normal, pIpC-treated hepatocytes exhibit an increase in DNA damage compared to wild-type cells

• however, a subset of hepatocytes resolve their DNA damage and divide

liver hypoplasia ( J:144766 )

• following partial hepatectomy, pIpC-treated livers exhibit reduced cellularity and endoreduplication compared to in similarly-treated wild-type mice

hematopoietic system

decreased bone marrow cell number ( J:144766 )

• the only viable bone marrow left after treatment with pIpC fails to exhibit recombination

cellular

decreased hepatocyte proliferation ( J:144766 )

• following partial hepatectomy, proliferation of pIpC-treated hepatocyte is decreased compared to in wild-type mice due to accumulation of DNA damage

• however, a subset of hepatocytes resolve their DNA damage and divide