Phenotypes Associated with This Genotype

Genotype
MGI:3832405

• Allelic Composition: Vhl^tm1Jae/Vhl^tm1Jae; Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:144666 )

• mice die at 6 to 8 weeks of age

liver/biliary system

increased hepatocyte proliferation ( J:144666 )

abnormal liver morphology ( J:144666 )

• at 6 weeks, the liver is friable and stippled with irregular yellow spots on a reddish black background unlike in wild-type mice

• hepatic vascularity is increased compared to in wild-type mice

increased liver weight ( J:144666 )

• at 6 weeks of age

abnormal hepatocyte morphology ( J:144666 )

• livers contain irregular, dilated, blood filled sinusoids and cytoplasmic vacuolizations within hepatocytes with eccentric nuclei unlike in wild-type mice

hepatic steatosis ( J:144666 )

• in a mixed micro- and macrovesicular steatotic pattern

hematopoietic system

increased hematocrit ( J:144666 )

reticulocytosis ( J:144666 )

cardiovascular system

abnormal blood vessel morphology ( J:144666 )

• hepatic vascularity is increased compared to in wild-type mice

growth/size/body

decreased body size ( J:144666 )

• mice are runted

increased liver weight ( J:144666 )

• at 6 weeks of age

integument

reddish skin ( J:144666 )

• of paws and unfurred skin by 4 to 6 weeks of age

cellular

increased hepatocyte proliferation ( J:144666 )