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Phenotypes Associated with This Genotype
Genotype
MGI:3832402
Allelic
Composition		 Gt(ROSA)26Sortm3(HIF1A*)Kael/Gt(ROSA)26Sor+
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background		 involves: 129S6/SvEvTac * BALB/c * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm3(HIF1A*)Kael mutation (1 available); any Gt(ROSA)26Sor mutation (942 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:144666 )
N
• mice exhibit a normal life span

liver/biliary system
abnormal hepatocyte morphology ( J:144666 )
• hepatocytes exhibit fine vacuolization unlike in wild-type mice but are otherwise normal
microvesicular hepatic steatosis ( J:144666 )
• moderate and in a microvesicular pattern

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory