Phenotypes for Dvl2 Dvl3 MGI:3831932 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Dvl2^tm1Awb/Dvl2⁺ Dvl3^tm1Awb/Dvl3⁺
Genetic Background	involves: 129S6/SvEvTac * Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl2^tm1Awb mutation (1 available); any Dvl2 mutation (33 available)
Dvl3^tm1Awb mutation (1 available); any Dvl3 mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal cardiac outflow tract development ( J:142392 )

• at E18.5, 11 of 28 mice exhibit conotruncal defects

persistent truncus arteriosus ( J:142392 )

• in 1 of 11 mice

double outlet right ventricle ( J:142392 )

• in 9 of 11 mice

transposition of great arteries ( J:142392 )

• in 1 of 11 mice

hearing/vestibular/ear

abnormal orientation of cochlear hair cell stereociliary bundles ( J:142392 )

nervous system

abnormal orientation of cochlear hair cell stereociliary bundles ( J:142392 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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