Phenotypes Associated with This Genotype

Genotype
MGI:3831931

• Allelic Composition: Dvl2^tm1Awb/Dvl2⁺; Dvl3^tm1Awb/Dvl3^tm1Awb
• Genetic Background: involves: 129S6/SvEvTac * Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

persistent truncus arteriosus ( J:142392 )

abnormal heart shape ( J:142392 )

• at P0

small heart ( J:142392 )

• at P0

craniofacial

short snout ( J:142392 )

embryo

short rostral-caudal axis ( J:142392 )

• at E18.5, mice exhibit shortening along the anterior-posterior axis

craniorachischisis ( J:142392 )

• in two mice

growth/size/body

herniated abdominal wall ( J:142392 )

• one mouse exhibited craniorachischisis, gastroschisis, and an absent tail

abnormal head morphology ( J:142392 )

short snout ( J:142392 )

hearing/vestibular/ear

abnormal orientation of cochlear hair cell stereociliary bundles ( J:142392 )

• mice exhibit rotated stereocillia bundles and mild patterning defects compared to in wild-type mice

• defects are more severe in mice also displaying craniorachischisis

limbs/digits/tail

short tail ( J:142392 )

absent tail ( J:142392 )

• one mouse exhibited craniorachischisis, gastroschisis, and an absent tail

kinked tail ( J:142392 )

nervous system

craniorachischisis ( J:142392 )

• in two mice

abnormal orientation of cochlear hair cell stereociliary bundles ( J:142392 )

• mice exhibit rotated stereocillia bundles and mild patterning defects compared to in wild-type mice

• defects are more severe in mice also displaying craniorachischisis