Phenotypes Associated with This Genotype

Genotype
MGI:3831926

• Allelic Composition: Dvl3^tm1Awb/Dvl3^tm1Awb; Vangl2^Lp/Vangl2⁺
• Genetic Background: involves: 129S6/SvEvTac * A * Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal neural tube morphology ( J:142392 )

• some mice develop similar neural tube defects as in Dvl3^tm1Awb Vangl2^Lp double heterozygotes

craniorachischisis ( J:142392 )

• in 6 of 16 mice

decreased cochlear outer hair cell number ( J:142392 )

• some mice exhibit a loss of outer hair cell rows compared to in wild-type mice along 5% to 20% of the cochlear length

increased cochlear hair cell number ( J:142392 )

• some mice exhibit additional rows of outer and inner cells in the apical region of the cochlea compared to in wild-type mice

abnormal orientation of cochlear hair cell stereociliary bundles ( J:142392 )

• the orientation of many cochlear hair cell stereociliary bundles is disrupted in the base and middle of the cochlear ducts

• mice with neural tube defects exhibit more severe orientation defects than in mice with normal neural tube closure

• stereociliary bundles in apical regions are rotated compared to in wild-type mice

cardiovascular system

abnormal cardiac outflow tract development ( J:142392 )

• mice exhibit conotruncal defects

hearing/vestibular/ear

decreased cochlear outer hair cell number ( J:142392 )

• some mice exhibit a loss of outer hair cell rows compared to in wild-type mice along 5% to 20% of the cochlear length

increased cochlear hair cell number ( J:142392 )

• some mice exhibit additional rows of outer and inner cells in the apical region of the cochlea compared to in wild-type mice

abnormal orientation of cochlear hair cell stereociliary bundles ( J:142392 )

• the orientation of many cochlear hair cell stereociliary bundles is disrupted in the base and middle of the cochlear ducts

• mice with neural tube defects exhibit more severe orientation defects than in mice with normal neural tube closure

• stereociliary bundles in apical regions are rotated compared to in wild-type mice

inner ear hypoplasia ( J:142392 )

• in mice with neural tube defects

embryo

abnormal neural tube morphology ( J:142392 )

• some mice develop similar neural tube defects as in Dvl3^tm1Awb Vangl2^Lp double heterozygotes

craniorachischisis ( J:142392 )

• in 6 of 16 mice