Phenotypes Associated with This Genotype

Genotype
MGI:3831924

• Allelic Composition: Dvl3^tm1Awb/Dvl3⁺; Vangl2^Lp/Vangl2⁺
• Genetic Background: involves: 129S6/SvEvTac * A * Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal neural tube morphology ( J:142392 )

• some mice develop neural tube abnormalities such as craniorachischisis and exencephaly

incomplete rostral neuropore closure ( J:142392 )

• some mice develop defects in rostral neural tube closure

craniorachischisis ( J:142392 )

• in 5 of 22 mice

decreased cochlear outer hair cell number ( J:142392 )

• some mice exhibit a loss of outer hair cell rows compared to in wild-type mice along 5% to 20% of the cochlear length

increased cochlear hair cell number ( J:142392 )

• some mice exhibit additional rows of outer and inner cells in the apical region of the cochlea compared to in wild-type mice

abnormal orientation of cochlear hair cell stereociliary bundles ( J:142392 )

• the orientation of cochlear hair cell stereociliary bundles in mice with neural tube defects is disrupted in the base and middle of the cochlear ducts

• stereociliary bundles in apical regions are rotated compared to in wild-type mice

exencephaly ( J:142392 )

• in 2 of 22 mice

cardiovascular system

cardiovascular system phenotype ( J:142392 )

N • hearts develop normally

hearing/vestibular/ear

decreased cochlear outer hair cell number ( J:142392 )

• some mice exhibit a loss of outer hair cell rows compared to in wild-type mice along 5% to 20% of the cochlear length

increased cochlear hair cell number ( J:142392 )

• some mice exhibit additional rows of outer and inner cells in the apical region of the cochlea compared to in wild-type mice

abnormal orientation of cochlear hair cell stereociliary bundles ( J:142392 )

• the orientation of cochlear hair cell stereociliary bundles in mice with neural tube defects is disrupted in the base and middle of the cochlear ducts

• stereociliary bundles in apical regions are rotated compared to in wild-type mice

inner ear hypoplasia ( J:142392 )

• in mice with neural tube defects

embryo

abnormal neural tube morphology ( J:142392 )

• some mice develop neural tube abnormalities such as craniorachischisis and exencephaly

incomplete rostral neuropore closure ( J:142392 )

• some mice develop defects in rostral neural tube closure

craniorachischisis ( J:142392 )

• in 5 of 22 mice