Phenotypes Associated with This Genotype

Genotype
MGI:3831915

• Allelic Composition: Dvl3^tm1Awb/Dvl3^tm1Awb
• Genetic Background: 129S6/SvEvTac-Dvl3^tm1Awb

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:142392 )

• despite being present in Mendelian ratios at E18.5, no mice survive to weaning

• however, survival can be rescued by expression of a Dvl1, Dvl2, or Dvl3 transgene

cardiovascular system

persistent truncus arteriosus ( J:142392 )

• in 7 of 11 mice

double outlet right ventricle ( J:142392 )

• in 4 of 11 mice

homeostasis/metabolism

cyanosis ( J:142392 )

• at birth

hearing/vestibular/ear

abnormal orientation of cochlear hair cell stereociliary bundles ( J:142392 )

• the orientation of many cochlear hair cell stereociliary bundles is disrupted in the base and middle of the cochlear ducts

• stereociliary bundles in apical regions are rotated compared to in wild-type mice

skeleton

split xiphoid process ( J:142392 )

• some mice exhibit xiphoid bifircation also observed in some wild-type mice

respiratory system

respiratory distress ( J:142392 )

• at birth

nervous system

abnormal orientation of cochlear hair cell stereociliary bundles ( J:142392 )

• the orientation of many cochlear hair cell stereociliary bundles is disrupted in the base and middle of the cochlear ducts

• stereociliary bundles in apical regions are rotated compared to in wild-type mice