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Phenotypes Associated with This Genotype
Genotype
MGI:3831754
Allelic
Composition		 Nfatc1tm3Glm/Nfatc1tm3Glm
Sh3bp2tm1Bjro/Sh3bp2tm1Bjro
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfatc1tm3Glm mutation (1 available); any Nfatc1 mutation (49 available)
Sh3bp2tm1Bjro mutation (0 available); any Sh3bp2 mutation (35 available)
Tg(Mx1-cre)1Cgn mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
skeleton phenotype ( J:144598 )
N
• induction of cre at 10 days of age prevents the diffuse bone loss and focal cystic changes characteristic of mice homozygote for the Sh3bp2tm1Bjro allele
abnormal osteoclast differentiation ( J:144598 )
• bone marrow cells fail to differentiate into osteoclasts in vitro
decreased osteoclast cell number ( J:144598 )
• a dramatic reduction in the number of TRAP+ cells is found iin the proximal humerus and distal femur

immune system
abnormal osteoclast differentiation ( J:144598 )
• bone marrow cells fail to differentiate into osteoclasts in vitro
stomach inflammation ( J:144598 )
• widespread inflammation is observed
decreased osteoclast cell number ( J:144598 )
• a dramatic reduction in the number of TRAP+ cells is found iin the proximal humerus and distal femur
lymph node inflammation ( J:144598 )
• widespread inflammation is observed
liver inflammation ( J:144598 )
• widespread inflammation is observed
lung inflammation ( J:144598 )
• widespread inflammation is observed

digestive/alimentary system
stomach inflammation ( J:144598 )
• widespread inflammation is observed

liver/biliary system
liver inflammation ( J:144598 )
• widespread inflammation is observed

respiratory system
lung inflammation ( J:144598 )
• widespread inflammation is observed

hematopoietic system
abnormal osteoclast differentiation ( J:144598 )
• bone marrow cells fail to differentiate into osteoclasts in vitro
decreased osteoclast cell number ( J:144598 )
• a dramatic reduction in the number of TRAP+ cells is found iin the proximal humerus and distal femur

cellular
abnormal osteoclast differentiation ( J:144598 )
• bone marrow cells fail to differentiate into osteoclasts in vitro

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory