Analysis Tools
skeleton
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• after cre induction, osteoclasts fail to develop from bone marrow cells in response to culturing with either osteoblasts, RANKL or M-CSF
• normal numbers of osteoclast progenitors are present in the bone marrow suggesting a defect in differentiation
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• some mice have overgrowth of the upper incisors with short or absent lower incisors
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• some mice have overgrowth of the upper incisors with short or absent lower incisors
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• some mice have overgrowth of the upper incisors with short or absent lower incisors
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• lower mandible has a marked retention of hypertrophic cartilage when cre is induced at 10 days of age
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• the number of osteoclasts per mm bone surface is severely reduced in mice with cre induction at 10 days of age
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• cre induction at 10 days of age leads to growth plate dysplasia, characterized by an increase in thickness, acellular areas, and the retention of hypertrophic chondrocytes beyond the chondro-osseous junction
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• cre-induction at 10 days of age leads to shortened long bones by 5 months of age
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short femur
(
J:144598
)
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• cre induction at 10 days of age leads to short, club-shaped femurs, with higher radiodensity at the distal portion
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short tibia
(
J:144598
)
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• cre induction at 10 days of age leads to short, club-shaped tibias, with higher radiodensity at the proximal portion
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• the bone volume to total volume fraction of femurs is twice that of controls when cre is induced at 10 days of age
• cre induction at 10 days of age also leads to other features of severe osteopetrosis, including improperly shaped long bones, and a failure to resorb calcified cartilage resulting in aberrant endochondral growth and ossification
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• cre induction at 10 days of age leads to a massive increase in calcified cartilage adjacent to the growth plates
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craniofacial
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• some mice have overgrowth of the upper incisors with short or absent lower incisors
|
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• some mice have overgrowth of the upper incisors with short or absent lower incisors
|
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• some mice have overgrowth of the upper incisors with short or absent lower incisors
|
|
• lower mandible has a marked retention of hypertrophic cartilage when cre is induced at 10 days of age
|
limbs/digits/tail
short femur
(
J:144598
)
|
• cre induction at 10 days of age leads to short, club-shaped femurs, with higher radiodensity at the distal portion
|
short tibia
(
J:144598
)
|
• cre induction at 10 days of age leads to short, club-shaped tibias, with higher radiodensity at the proximal portion
|
hematopoietic system
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• after cre induction, osteoclasts fail to develop from bone marrow cells in response to culturing with either osteoblasts, RANKL or M-CSF
• normal numbers of osteoclast progenitors are present in the bone marrow suggesting a defect in differentiation
|
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• the number of osteoclasts per mm bone surface is severely reduced in mice with cre induction at 10 days of age
|
immune system
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• after cre induction, osteoclasts fail to develop from bone marrow cells in response to culturing with either osteoblasts, RANKL or M-CSF
• normal numbers of osteoclast progenitors are present in the bone marrow suggesting a defect in differentiation
|
|
• the number of osteoclasts per mm bone surface is severely reduced in mice with cre induction at 10 days of age
|
cellular
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• after cre induction, osteoclasts fail to develop from bone marrow cells in response to culturing with either osteoblasts, RANKL or M-CSF
• normal numbers of osteoclast progenitors are present in the bone marrow suggesting a defect in differentiation
|
growth/size/body
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• some mice have overgrowth of the upper incisors with short or absent lower incisors
|
|
• some mice have overgrowth of the upper incisors with short or absent lower incisors
|
|
• some mice have overgrowth of the upper incisors with short or absent lower incisors
|
|
• lower mandible has a marked retention of hypertrophic cartilage when cre is induced at 10 days of age
|
