Phenotypes Associated with This Genotype

Genotype
MGI:3831696

• Allelic Composition: F2^tm1Jld/F2^tm1Sjd; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:144572 )

• following induction with poly(I:C)

cardiovascular system

abnormal heart morphology ( J:144572 )

• following induction with poly(I:C), hemorrhaging in the heart leads to muscle ischemia/necrosis, neutrophil infiltrates and early granulation tissue, and disruption of muscle architecture by amorphous plasma and matrix proteins

cardiac fibrosis ( J:144572 )

• aged uninduced mice develop hemosiderin depositions and cardiac fibrosis unlike wild-type mice

hemorrhage ( J:144572 )

• following induction with poly(I:C), nearly all mice exhibit cardiac hemorrhaging with some hemorrhaging in the pleural cavity (in 46% of mice), intracranial cavity (in 46% of mice), or focally within the skeletal muscle (in 18% of mice) unlike in wild-type mice

• however, without induction with poly(I:C) no hemorrhaging is observed

hemothorax ( J:144572 )

• following induction with poly(I:C), 46% of mice exhibit some hemorrhaging in the pleural cavity

testicular hemorrhage ( J:144572 )

• hemorrhaging is occasionally observed in the testes following induction with poly(I:C)

gastrointestinal hemorrhage ( J:144572 )

• hemorrhaging is occasionally observed in the bowels following induction with poly(I:C)

heart hemorrhage ( J:144572 )

• nearly all mice exhibit cardiac hemorrhaging following induction with poly(I:C)

• hemorrhaging in the heart leads to muscle ischemia/necrosis, neutrophil infiltrates and early granulation tissue, and disruption of muscle architecture by amorphous plasma and matrix proteins

intracranial hemorrhage ( J:144572 )

• following induction with poly(I:C), 46% of mice exhibit intracranial hemorrhaging; bleeding is often dural based with ventricular and parenchymal hemorrhaging occurring and parenchymal bleeding encountered in the medulla, cerebellum and hippocampus

cerebellum hemorrhage ( J:144572 )

• following induction with poly(I:C)

muscle hemorrhage ( J:144572 )

• following induction with poly(I:C), 18% of mice exhibit focal hemorrhaging within skeletal muscle

spinal hemorrhage ( J:144572 )

• hemorrhaging is occasionally observed in the spinal canal following induction with poly(I:C)

skin hemorrhage ( J:144572 )

• hemorrhaging is occasionally observed in the skin following induction with poly(I:C)

homeostasis/metabolism

abnormal blood coagulation ( J:144572 )

• clotting time is modestly increased compared to in wild-type mice

• following induction with poly(I:C), clotting time is severely increased compared to in wild-type mice

• however, platelet counts and fibrinogen amounts are normal, and treatment with prothrombin restores normal clotting times

increased bleeding time ( J:144572 )

• following induction with poly(I:C)

nervous system

intracranial hemorrhage ( J:144572 )

• following induction with poly(I:C), 46% of mice exhibit intracranial hemorrhaging; bleeding is often dural based with ventricular and parenchymal hemorrhaging occurring and parenchymal bleeding encountered in the medulla, cerebellum and hippocampus

cerebellum hemorrhage ( J:144572 )

• following induction with poly(I:C)

spinal hemorrhage ( J:144572 )

• hemorrhaging is occasionally observed in the spinal canal following induction with poly(I:C)

integument

skin hemorrhage ( J:144572 )

• hemorrhaging is occasionally observed in the skin following induction with poly(I:C)

petechiae ( J:144572 )

• occasionally following induction with poly(I:C)

reproductive system

testicular hemorrhage ( J:144572 )

• hemorrhaging is occasionally observed in the testes following induction with poly(I:C)

respiratory system

hemothorax ( J:144572 )

• following induction with poly(I:C), 46% of mice exhibit some hemorrhaging in the pleural cavity

digestive/alimentary system

gastrointestinal hemorrhage ( J:144572 )

• hemorrhaging is occasionally observed in the bowels following induction with poly(I:C)

muscle

muscle hemorrhage ( J:144572 )

• following induction with poly(I:C), 18% of mice exhibit focal hemorrhaging within skeletal muscle

endocrine/exocrine glands

testicular hemorrhage ( J:144572 )

• hemorrhaging is occasionally observed in the testes following induction with poly(I:C)