About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3831332
Allelic
Composition
Nek1kat/Nek1kat
Genetic
Background
involves: C3HeB/FeJLe * C57BL/6J * RBF/Dn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nek1kat mutation (1 available); any Nek1 mutation (43 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 22% survive beyond 1 year

renal/urinary system
• bilateral polycystic kidney disease with a progressive increase in the number and size of cysts in the kidney cortex, with slower progression than in kat-2J homozygotes (J:37799)
• cysts seem to be dilated proximal tubules and Bowman spaces (J:37799)

nervous system
• at 7 months of age the lateral, third, and fourth ventricles and cerebral aqueduct are dilated
• at 7 months of age the lateral, third, and fourth ventricles and cerebral aqueduct are dilated
• at 7 months of age the choroid plexus has multiple large cysts present in the interstitium
• at 7 months of age the lateral, third, and fourth ventricles and cerebral aqueduct are dilated
• most of the olfactory glomerular and external granular layers are absent, and in places are replaced by lacy vacuolated tissue
• olfactory lobes are approximately half normal size

growth/size/body

craniofacial
• foreshortened face, particularly the snout

hematopoietic system
• hematocrit is slightly reduced in many young homozygotes and falls progressively after 200 days of age

Mouse Models of Human Disease
OMIM ID Ref(s)
Polycystic Kidney Disease, Autosomal Recessive; ARPKD 263200 J:37799


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/19/2016
MGI 6.04
The Jackson Laboratory