Phenotypes for Atm Lig4 MGI:3831183 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Atm^tm1Pmc/Atm^tm1Pmc Lig4^tm1Icrf/Lig4^tm1Icrf
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atm^tm1Pmc mutation (0 available); any Atm mutation (169 available)
Lig4^tm1Icrf mutation (0 available); any Lig4 mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality ( J:144172 )

cellular

decreased cellular sensitivity to ionizing radiation ( J:144172 )

• ionizing radiation-induced apoptosis in the developing nervous system is almost completely blocked

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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