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Phenotypes Associated with This Genotype
Genotype
MGI:3831179
Allelic
Composition		 Lig4tm1Pmc/Lig4tm1Pmc
Mre11atm1Jpt/Mre11atm1Jpt
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: 129S1/SvImJ * 129S7/SvEvBrd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lig4tm1Pmc mutation (0 available); any Lig4 mutation (46 available)
Mre11atm1Jpt mutation (1 available); any Mre11a mutation (49 available)
Tg(Nes-cre)1Kln mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
ataxia ( J:144172 )
• at 7 to 9 months, mice develop severe hind-limb ataxia or unknown etiology

nervous system
nervous system phenotype ( J:144172 )
N
• unlike in mice with Lig4tm1Pmc/Lig4tm1Pmc Tg(Nes-cre)1Kln, mice do not exhibit any increased apoptosis in the nervous system, and microencephaly is rescued

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory