Analysis Tools
nervous system
|
• at E13.5 and E15.5, neural tissue apoptosis is increased compared to in wild-type mice
• however, brain morphology is otherwise normal
|
|
• brain size is reduced as much as 40% compared to in littermate controls
|
homeostasis/metabolism
|
• DNA damage in the brain accumulates with age unlike in wild-type mice
• mice fail to repair ionizing radiation-induced DNA damage after 1 week compared to similarly treated wild-type mice that exhibit repair after 24 hours
|
behavior/neurological
cellular
|
• DNA damage in the brain accumulates with age unlike in wild-type mice
• mice fail to repair ionizing radiation-induced DNA damage after 1 week compared to similarly treated wild-type mice that exhibit repair after 24 hours
|
growth/size/body
microcephaly
(
J:144172
)
