About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3830514
Allelic
Composition		 Smarca4tm1.2Pcn/Smarca4tm1.2Pcn
Tg(Lck-cre)1Cwi/0
Tg(LCKprBCL2L1)12Sjk/0
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smarca4tm1.2Pcn mutation (1 available); any Smarca4 mutation (109 available)
Tg(Lck-cre)1Cwi mutation (3 available)
Tg(LCKprBCL2L1)12Sjk mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell morphology ( J:144072 )
• 9% of the post-DN3 population is composed of CD4-DN4 cells compared to 25% in Smarca4tm1Tich/Smarca4tm1Tich Tg(Lck-cre)1Cwi Tg(LCKprBCL2L1)12Sjk mice
• 52% of the post-DN3 population is composed of CD4+DN4 cells compared to 39% in Smarca4tm1Tich/Smarca4tm1Tich Tg(Lck-cre)1Cwi Tg(LCKprBCL2L1)12Sjk mice
increased thymocyte number ( J:144072 )
• 8-fold compared to in Smarca4tm1Gcr/Smarca4tm1Tich Tg(Lck-cre)1Cwi mice
increased double-negative T cell number ( J:144072 )
• the DN2 population increases
• the DN3 population is rescued but is growth arrested
• the post-DN3 population is increased
decreased double-positive T cell number ( J:144072 )
• relative to DN4 cellularity

hematopoietic system
abnormal T cell morphology ( J:144072 )
• 9% of the post-DN3 population is composed of CD4-DN4 cells compared to 25% in Smarca4tm1Tich/Smarca4tm1Tich Tg(Lck-cre)1Cwi Tg(LCKprBCL2L1)12Sjk mice
• 52% of the post-DN3 population is composed of CD4+DN4 cells compared to 39% in Smarca4tm1Tich/Smarca4tm1Tich Tg(Lck-cre)1Cwi Tg(LCKprBCL2L1)12Sjk mice
increased thymocyte number ( J:144072 )
• 8-fold compared to in Smarca4tm1Gcr/Smarca4tm1Tich Tg(Lck-cre)1Cwi mice
increased double-negative T cell number ( J:144072 )
• the DN2 population increases
• the DN3 population is rescued but is growth arrested
• the post-DN3 population is increased
decreased double-positive T cell number ( J:144072 )
• relative to DN4 cellularity

endocrine/exocrine glands
increased thymocyte number ( J:144072 )
• 8-fold compared to in Smarca4tm1Gcr/Smarca4tm1Tich Tg(Lck-cre)1Cwi mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory