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Phenotypes Associated with This Genotype
Genotype
MGI:3830513
Allelic
Composition		 Smarca4tm1.2Pcn/Smarca4tm1.2Pcn
Tg(Lck-cre)1Cwi/0
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smarca4tm1.2Pcn mutation (1 available); any Smarca4 mutation (110 available)
Tg(Lck-cre)1Cwi mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell morphology ( J:144072 )
• 14% of the post-DN3 population is composed of CD4+CD8- cells compared to 38% in Smarca4tm1Tich/Smarca4tm1Tich Tg(Lck-cre)1Cwi mice
• unlike in Smarca4tm1Tich/Smarca4tm1Tich Tg(Lck-cre)1Cwi mice, a CD4-CD8+ population analogous to immature single positive cells is observed
decreased double-negative T cell number ( J:144072 )
• post-DN3 cells are virtually absent

hematopoietic system
abnormal T cell morphology ( J:144072 )
• 14% of the post-DN3 population is composed of CD4+CD8- cells compared to 38% in Smarca4tm1Tich/Smarca4tm1Tich Tg(Lck-cre)1Cwi mice
• unlike in Smarca4tm1Tich/Smarca4tm1Tich Tg(Lck-cre)1Cwi mice, a CD4-CD8+ population analogous to immature single positive cells is observed
decreased double-negative T cell number ( J:144072 )
• post-DN3 cells are virtually absent

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory