Phenotypes Associated with This Genotype

Genotype
MGI:3830385

• Allelic Composition: Inpp5d^tm1Wgk/Inpp5d^tm1.1Wgk; Tg(Mx1-cre)1Cgn/0
• Genetic Background: B6.Cg-Inpp5d^tm1Wgk/Inpp5d^tm1.1Wgk Tg(Mx1-cre)1Cgn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal myeloid leukocyte morphology ( J:144110 )

• Cd11b⁺Gr⁺ myeloid suppressor cell (MySC) numbers are significantly increased in both the spleen and mesenteric lymph nodes after cre induction

• expansion is 5- to 10-fold higher than controls in the spleen and 10- to 20- fold higher in the lymph nodes after cre induction

• when cre expression is only partially induced, significant increase in MySC numbers are still observed

abnormal leukocyte physiology ( J:144110 )

• Cd11b ⁺Gr⁺ myeloid suppressor cell (MySC) have an enhanced ability on a per cell basis to suppress allogenic T cells in a mixed lymphocyte reaction

• priming of allogenic T cells by mutant splenocytes is also poor, an effect attributable to the enhanced MySC activity

hematopoietic system

abnormal myeloid leukocyte morphology ( J:144110 )

• Cd11b⁺Gr⁺ myeloid suppressor cell (MySC) numbers are significantly increased in both the spleen and mesenteric lymph nodes after cre induction

• expansion is 5- to 10-fold higher than controls in the spleen and 10- to 20- fold higher in the lymph nodes after cre induction

• when cre expression is only partially induced, significant increase in MySC numbers are still observed

abnormal leukocyte physiology ( J:144110 )

• Cd11b ⁺Gr⁺ myeloid suppressor cell (MySC) have an enhanced ability on a per cell basis to suppress allogenic T cells in a mixed lymphocyte reaction

• priming of allogenic T cells by mutant splenocytes is also poor, an effect attributable to the enhanced MySC activity