Phenotypes Associated with This Genotype

Genotype
MGI:3830057

• Allelic Composition: Il17a^tm1Yiw/Il17a^tm1Yiw; Il17f^tm2Yiw/Il17f^tm2Yiw
• Genetic Background: B6.129P2-Il17a^tm1Yiw Il17f^tm2Yiw

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to infection induced morbidity/mortality ( J:160680 )

• decreased survival rate in response to i.v C. albicans NBRC1385 infection

immune system

increased IgG1 level ( J:143719 )

• IgG1 sera levels are elevated 2-4 fold in the sera of 8-10 week old mice compared to controls

increased IgG2a level ( J:143719 )

• IgG2a sera levels are elevated 2-4 fold in the sera of 8-10 week old mice compared to controls

increased IgG2b level ( J:143719 )

• IgG2b sera levels are elevated 2-4 fold in the sera of 8-10 week old mice compared to controls

decreased IgG3 level ( J:143719 )

• IgG3 sera levels are decreased in the sera of 8-10 week old mice compared to controls

enlarged submandibular lymph nodes ( J:143719 )

• submandibular lymph node size increase with age until they are almost 3-fold heavier by 12-16 weeks of age

• this increase is due to opportunistic S. aureus infection, with lymph nodes shrinking after antibiotic treatment

increased susceptibility to infection induced morbidity/mortality ( J:160680 )

• decreased survival rate in response to i.v C. albicans NBRC1385 infection

hematopoietic system

increased IgG1 level ( J:143719 )

• IgG1 sera levels are elevated 2-4 fold in the sera of 8-10 week old mice compared to controls

increased IgG2a level ( J:143719 )

• IgG2a sera levels are elevated 2-4 fold in the sera of 8-10 week old mice compared to controls

increased IgG2b level ( J:143719 )

• IgG2b sera levels are elevated 2-4 fold in the sera of 8-10 week old mice compared to controls

decreased IgG3 level ( J:143719 )

• IgG3 sera levels are decreased in the sera of 8-10 week old mice compared to controls