Phenotypes Associated with This Genotype

Genotype
MGI:3830056

• Allelic Composition: Il17a^tm1Yiw/Il17a^tm1Yiw; Il17f^tm2Yiw/Il17f^tm2Yiw
• Genetic Background: involves: 129P2/OlaHsd * BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased IgG1 level ( J:143719 )

• IgG1 sera levels are elevated 2-4 fold in the sera of 8-10 week old mice compared to controls

increased IgG2a level ( J:143719 )

• IgG2a sera levels are elevated 2-4 fold in the sera of 8-10 week old mice compared to controls

increased IgG2b level ( J:143719 )

• IgG2b sera levels are elevated 2-4 fold in the sera of 8-10 week old mice compared to controls

decreased IgG3 level ( J:143719 )

• IgG3 sera levels are decreased in the sera of 8-10 week old mice compared to controls

enlarged submandibular lymph nodes ( J:143719 )

• submandibular lymph node size increase with age until they are almost 3-fold heavier by 12-16 weeks of age

• this increase is due to opportunistic S. aureus infection, with lymph nodes shrinking after antibiotic treatment

nasal inflammation ( J:143719 )

• mice develop mucocutaneous abscesses around the nose and mouth that result from an opportunistic S. aureus infection

increased susceptibility to bacterial infection ( J:143719 )

• mice develop mucocutaneous abscesses around the nose and mouth that result from an opportunistic S. aureus infection

• S. aureus is readily culturable from mucosal surfaces of the nose and mouth but is not culturable from controls

• mice have the same resistance to systemic infection of S. aureus as determined by survival curves and the amount of colony forming units in kidney homegenates after inoculation with S. aureus

craniofacial

mouth mucosal ulcer ( J:143719 )

• mice develop mucocutaneous abscesses around the nose and mouth that result from an opportunistic S. aureus infection

digestive/alimentary system

mouth mucosal ulcer ( J:143719 )

• mice develop mucocutaneous abscesses around the nose and mouth that result from an opportunistic S. aureus infection

respiratory system

nasal inflammation ( J:143719 )

• mice develop mucocutaneous abscesses around the nose and mouth that result from an opportunistic S. aureus infection

hematopoietic system

increased IgG1 level ( J:143719 )

• IgG1 sera levels are elevated 2-4 fold in the sera of 8-10 week old mice compared to controls

increased IgG2a level ( J:143719 )

• IgG2a sera levels are elevated 2-4 fold in the sera of 8-10 week old mice compared to controls

increased IgG2b level ( J:143719 )

• IgG2b sera levels are elevated 2-4 fold in the sera of 8-10 week old mice compared to controls

decreased IgG3 level ( J:143719 )

• IgG3 sera levels are decreased in the sera of 8-10 week old mice compared to controls

growth/size/body

mouth mucosal ulcer ( J:143719 )

• mice develop mucocutaneous abscesses around the nose and mouth that result from an opportunistic S. aureus infection