Phenotypes for Il1rn Il17a Il17f MGI:3830055 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Il17a^tm1Yiw/Il17a^tm1Yiw Il17f^tm1Yiw/Il17f^tm1Yiw Il1rn^tm1Yiw/Il1rn^tm1Yiw
Genetic Background	involves: 129 * BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il17a^tm1Yiw mutation (0 available); any Il17a mutation (24 available)
Il17f^tm1Yiw mutation (0 available); any Il17f mutation (23 available)
Il1rn^tm1Yiw mutation (0 available); any Il1rn mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

rheumatoid arthritis ( J:143719 )

• only about 20% of mice develop arthritis compared to almost the 100% incidence of arthritis in mice homozygote for just the Il1rn^tm1Yiw allele

• severity of disease of those affected is also significantly less than Il1rn^tm1Yiw homozygotes

skeleton

rheumatoid arthritis ( J:143719 )

• only about 20% of mice develop arthritis compared to almost the 100% incidence of arthritis in mice homozygote for just the Il1rn^tm1Yiw allele

• severity of disease of those affected is also significantly less than Il1rn^tm1Yiw homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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