Phenotypes Associated with This Genotype

Genotype
MGI:3830000

• Allelic Composition: Myo18b^tm1Jyo/Myo18b^tm1Jyo
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:142442 )

• die around E11.5 - E13.5

cardiovascular system

abnormal cardinal vein morphology ( J:142442 )

• the lumens of the right and left cardinal veins are morbidly enlarged

abnormal myocardium layer morphology ( J:142442 )

• at E10.5 to E12.5

fetal cardiomyocyte disarray ( J:142442 )

• at E10.5, alignment of parallel thick and thin filaments is disorganized and the distribution of thick and thin filaments is unbalanced

dilated heart right atrium ( J:142442 )

• the lumen is morbidly enlarged

pericardial effusion ( J:142442 )

• variable degrees of pericardial effusion are seen

internal hemorrhage ( J:142442 )

• some embryos show severe hemorrhage in the cardiac and ventral body wall regions

muscle

abnormal myocardium layer morphology ( J:142442 )

• at E10.5 to E12.5

homeostasis/metabolism

pericardial effusion ( J:142442 )

• variable degrees of pericardial effusion are seen