Myo18b^tm1Jyo
Targeted Allele Detail

Summary

• Symbol: Myo18b^tm1Jyo
• Name: myosin XVIIIb; targeted mutation 1, Jun Yokota
• MGI ID: MGI:3829997
• Gene: Myo18b Location: Chr5:112836742-113044228 bp, - strand Genetic Position: Chr5, 54.8 cM, cytoband F
• Alliance: Myo18b^tm1Jyo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:142442
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A construct containing an nls-LacZ cassette and neo cassette was inserted in exon 2 after the translation initiation codon via homologous recombination. Western blot analysis of whole embryo lysates confirmed the absence of protein expression in homozygotes. LacZ expression is similar to endogenous gene expression. (J:142442)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Myo18b Mutation: 114 strains or lines available

References

• Original: J:142442 Ajima R, et al., Deficiency of Myo18B in mice results in embryonic lethality with cardiac myofibrillar aberrations. Genes Cells. 2008 Oct;13(10):987-99
• All: 1 reference(s)