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Phenotypes Associated with This Genotype
Genotype
MGI:3829712
Allelic
Composition		 Il2rgtm1Cgn/Il2rgtm1Cgn
Rag2tm1Fwa/Rag2tm1Fwa
Genetic
Background		 involves: 129P2/OlaHsd * 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2rgtm1Cgn mutation (4 available); any Il2rg mutation (133 available)
Rag2tm1Fwa mutation (45 available); any Rag2 mutation (115 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased NK cell number ( J:142654 )
• Ncr(NKp46)+ NK1.1+ NK cells are essentially absent
• the NKp46+CD127+ NK1.1- subset of intestinal natural killer cells is also absent
abnormal interleukin secretion ( J:142654 )
• there is no interleukin 22 (IL-22) secretion by colonic lamina propia cells isolated from mice infected with C. rodentium compared to controls that secrete detectable amounts of IL-22
increased susceptibility to bacterial infection ( J:142654 )
• mice are extremely susceptible to C. rodentium infection, with all mice showing dramatic weight loss and succumbing to infection by day 7
• controls (Rag2 knockouts, Rag2 and Il2rg double knockouts) are not susceptible to infection

hematopoietic system
decreased NK cell number ( J:142654 )
• Ncr(NKp46)+ NK1.1+ NK cells are essentially absent
• the NKp46+CD127+ NK1.1- subset of intestinal natural killer cells is also absent

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/31/2026
MGI 6.24 		The Jackson Laboratory