Phenotypes Associated with This Genotype

Genotype
MGI:3829507

• Allelic Composition: Nos2^tm1Lau/Nos2^tm1Lau; Tg(Thy1-APPSwDutIowa)BWevn/?
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

increased neuron apoptosis ( J:132221 )

amyloid beta deposits ( J:132221 , J:143551 )

• amyloid beta deposits in the hippocampus, in the subiculum and thalamus (J:132221)

• deposits are observed by 52 weeks of age (J:143551)

abnormal brain interneuron morphology ( J:143551 )

• 65% loss of NPY interneurons in the hippocampus

abnormal hippocampus CA3 region morphology ( J:132221 , J:143551 )

• thinning of the CA3 and subiculum, with a 40% loss of neurons in the CA3 region (J:132221)

• neuronal loss (J:143551)

decreased subiculum size ( J:132221 , J:143551 )

• 35% loss of neurons in the subiculum (J:132221)

• neuronal loss (J:143551)

tau protein deposits ( J:132221 )

• mice show intraneuronal aggregrates of tau

• hyperphosphorylated tau is seen in the brain and in neuronal processes associated with blood vessels

decreased neuron number ( J:143551 )

• neuronal loss is observed in hippocampus, subiculum and CA3

neurodegeneration ( J:132221 )

• 30% loss of NeuN-immunopositive neurons in the hippocampus, 35% loss in the subiculum, and 40% loss in the CA3 region of the hippocampus

• loss of neuropeptide Y-immunopositive neurons particularly in the CA3 region and in the subiculum

hippocampal neuron degeneration ( J:132221 )

• 30% loss of neurons in the hippocampus

• 50% reduction in neuropeptide Y-immunopositive neurons overall throughout the hippocampus, a 65% reduction in the CA3 region, and 50% reduction in the subiculum

homeostasis/metabolism

amyloid beta deposits ( J:132221 , J:143551 )

• amyloid beta deposits in the hippocampus, in the subiculum and thalamus (J:132221)

• deposits are observed by 52 weeks of age (J:143551)

behavior/neurological

abnormal spatial reference memory ( J:132221 )

• mice make more errors in the radial-arm water maze than single Tg(Thy1-APPSwDutIowa)BWevn transgenics, especially on subsequent days, indicating slowed learning and/or retrieval of the task

• mice show increased impaired performance on the Barnes maze compared to single Tg(Thy1-APPSwDutIowa)BWevn transgenics

cellular

increased neuron apoptosis ( J:132221 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:132221