Phenotypes Associated with This Genotype

Genotype
MGI:3829423

• Allelic Composition: Apc^Min/Apc⁺; Tg(Rorc-EGFP)1Ebe/?
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal effector T cell morphology ( J:137020 )

• in the mesenteric lymph node (MLN), the ratio of IL-17 producing cells to Foxp3-positive cells within the GFP-positive T cell population is significantly decreased compared to controls

• this observation is compared to an induced-colitis control where ratio of the two effector cell populations remain the same in the MLN despite inflammation occuring

enlarged mesenteric lymph nodes ( J:137020 )

• mesenteric lymph nodes are hyperplastic

lymph node hyperplasia ( J:137020 )

• mesenteric lymph nodes are hyperplastic

digestive/alimentary system

intestine polyps ( J:137020 )

• ileal polyps occur in these mice

colon polyps ( J:137020 )

• occur in these mice

hematopoietic system

abnormal effector T cell morphology ( J:137020 )

• in the mesenteric lymph node (MLN), the ratio of IL-17 producing cells to Foxp3-positive cells within the GFP-positive T cell population is significantly decreased compared to controls

• this observation is compared to an induced-colitis control where ratio of the two effector cell populations remain the same in the MLN despite inflammation occuring