Phenotypes Associated with This Genotype

Genotype
MGI:3829020

• Allelic Composition: Ctcf^tm2Gal/Ctcf^tm2Gal; Tg(Lck-cre)1Cwi/0; Tg(TcraTcrb)425Cbn/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T cell differentiation ( J:143271 )

• T cell development is more severely arrested than in Ctcf^tm1Laat/Ctcf^tm1Laat Tg(Lck-cre)1Cwi mice

increased double-negative T cell number ( J:143271 )

decreased double-positive T cell number ( J:143271 )

decreased T cell number ( J:143271 )

• mice exhibit an almost complete lack of mature T cells in the spleen

decreased CD4-positive, alpha-beta T cell number ( J:143271 )

increased single-positive T cell number ( J:143271 )

• the number of immature single positive cells in the thymus is increased compared to in wild-type mice

hematopoietic system

abnormal T cell differentiation ( J:143271 )

• T cell development is more severely arrested than in Ctcf^tm1Laat/Ctcf^tm1Laat Tg(Lck-cre)1Cwi mice

increased double-negative T cell number ( J:143271 )

decreased T cell number ( J:143271 )

• mice exhibit an almost complete lack of mature T cells in the spleen

decreased double-positive T cell number ( J:143271 )

decreased CD4-positive, alpha-beta T cell number ( J:143271 )

increased single-positive T cell number ( J:143271 )

• the number of immature single positive cells in the thymus is increased compared to in wild-type mice