Analysis Tools
immune system
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• cells at the DN3L to immature single positive stage are smaller than in wild-type mice while double positive cells are larger than in wild-type mice
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• alpha beta T cell differentiation is defective
• the number of DN3, DN4 and immature single positive cells is increased compared to in wild-type mice
• mice exhibit only a 4-fold increase in thymocytes during the transition from immature single positive to double positive T cells compared to a 90-fold increase in wild-type mice
• however, sigma delta T cell differentiation and TCR rearrangement are normal
• mice exhibit a defect in the transition from immature single positive cells to double positive cells
• the number of immature single positive T cells undergoing cell cycling is half as many as in wild-type mice
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• the number of double negative DN3 and DN4 cells is increased compared to in wild-type mice
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• the numbers of mature CD4+ and CD8+ cells in the spleen and lymph nodes are reduced compared to in wild-type mice
• however, the ratio of mature single positive cells to double positive cells is normal
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• the numbers of mature CD4+ and CD8+ cells in the spleen and lymph nodes are reduced compared to in wild-type mice
• however, the ratio of mature single positive cells to double positive cells is normal
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• the number of mature single positive T cells is decreased compared to in wild-type mice
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• the number of immature single positive cells in the thymus is increased compared to in wild-type mice
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hematopoietic system
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• cells at the DN3L to immature single positive stage are smaller than in wild-type mice while double positive cells are larger than in wild-type mice
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• alpha beta T cell differentiation is defective
• the number of DN3, DN4 and immature single positive cells is increased compared to in wild-type mice
• mice exhibit only a 4-fold increase in thymocytes during the transition from immature single positive to double positive T cells compared to a 90-fold increase in wild-type mice
• however, sigma delta T cell differentiation and TCR rearrangement are normal
• mice exhibit a defect in the transition from immature single positive cells to double positive cells
• the number of immature single positive T cells undergoing cell cycling is half as many as in wild-type mice
|
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• the number of double negative DN3 and DN4 cells is increased compared to in wild-type mice
|
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• the numbers of mature CD4+ and CD8+ cells in the spleen and lymph nodes are reduced compared to in wild-type mice
• however, the ratio of mature single positive cells to double positive cells is normal
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• the numbers of mature CD4+ and CD8+ cells in the spleen and lymph nodes are reduced compared to in wild-type mice
• however, the ratio of mature single positive cells to double positive cells is normal
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• the number of mature single positive T cells is decreased compared to in wild-type mice
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• the number of immature single positive cells in the thymus is increased compared to in wild-type mice
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endocrine/exocrine glands
