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Phenotypes Associated with This Genotype
Genotype
MGI:3829009
Allelic
Composition
Cavin1tm1Pfp/Cavin1tm1Pfp
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cavin1tm1Pfp mutation (1 available); any Cavin1 mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• fewer than expected mice are present at weaning

homeostasis/metabolism
• serum leptin and adiponectin levels are lower than in wild-type mice
• mice display a lower resting metabolic rate compared to wild-type mice

growth/size/body
• mice are leaner than wild-type mice

cellular
• in lung epithelium and skeletal muscle (J:143425)
• absence of caveolae in microvascular endothelia (J:205741)

behavior/neurological

cardiovascular system
• absence of caveolae in microvascular endothelia
• gaps in the lung capillary

respiratory system
• gaps in the lung capillary

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
congenital generalized lipodystrophy type 4 DOID:0111138 OMIM:613327
J:150419


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/12/2019
MGI 6.13
The Jackson Laboratory