Phenotypes Associated with This Genotype

Genotype
MGI:3826434

• Allelic Composition: Pkd2^tm1Gwu/Pkd2^tm1Gwu
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Cystic kidneys and other phenotypes in Pkd2^tm1Gwu/Pkd2^tm1Gwu and Pkhd1^tm1Gwu/Pkhd1^tm1Gwu mice

mortality/aging

mortality/aging ( J:143124 )

N • unlike mice homozygous for a null allele, mice survive into adulthood

renal/urinary system

kidney cyst ( J:143124 )

• by 6 months, 23% of mice exhibit microscopic cyst formation and/or tubular dilation

• by 12 months, all mice develop kidney cysts

abnormal papillary duct morphology ( J:143124 )

• mice exhibit focal dilation of papillary collecting ducts

increased glomerular capsule space ( J:143124 )

• mice exhibit expansion of Bowman's space

dilated renal tubule ( J:143124 )

• by 6 months, 23% of mice exhibit microscopic cyst formation and/or tubular dilation

dilated proximal convoluted tubule ( J:143124 )

• mice exhibit patchy dilation of proximal tubules

liver/biliary system

dilated bile duct ( J:143124 )

• 10% of mice exhibit gross dilation of the common bile duct

• mice exhibit dilation of billiary ducts and central veins with lymphocyte infiltration and/or necrosis

abnormal liver morphology ( J:143124 )

• mice exhibit dilation of the hepatic vein with patchy, periportal, lymphocytic infiltration

liver cyst ( J:143124 )

endocrine/exocrine glands

dilated pancreatic duct ( J:143124 )

• mice exhibit dilation of the small and large pancreatic ducts

dilated bile duct ( J:143124 )

• 10% of mice exhibit gross dilation of the common bile duct

• mice exhibit dilation of billiary ducts and central veins with lymphocyte infiltration and/or necrosis

pancreas cyst ( J:143124 )

growth/size/body

pancreas cyst ( J:143124 )

kidney cyst ( J:143124 )

• by 6 months, 23% of mice exhibit microscopic cyst formation and/or tubular dilation

• by 12 months, all mice develop kidney cysts

liver cyst ( J:143124 )

postnatal growth retardation ( J:143124 )

• 15% of mice exhibit growth retardation

digestive/alimentary system

dilated pancreatic duct ( J:143124 )

• mice exhibit dilation of the small and large pancreatic ducts

cardiovascular system

abnormal hepatic vein morphology ( J:143124 )

• mice exhibit dilation of the hepatic vein