Pkd2^tm1Gwu
Targeted Allele Detail

Summary

• Symbol: Pkd2^tm1Gwu
• Name: polycystin 2, transient receptor potential cation channel; targeted mutation 1, Guanqing Wu
• MGI ID: MGI:3826433
• Synonyms: Pkd2^nf3
• Gene: Pkd2 Location: Chr5:104607316-104653685 bp, + strand Genetic Position: Chr5, 50.68 cM
• Alliance: Pkd2^tm1Gwu page

Cystic kidneys and other phenotypes in Pkd2^tm1Gwu/Pkd2^tm1Gwu and Pkhd1^tm1Gwu/Pkhd1^tm1Gwu mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:143124
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Hypomorph)
• Mutation: Insertion
• Mutation details: A neo cassette flanked by two FRT sites was inserted upstream of exon 3 and two loxP sites were inserted to flank exon 3. Reduced protein expression was confirmed by western blot analysis on kidney extracts. This allele is hypomorphic. (J:143124)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pkd2 Mutation: 84 strains or lines available

References

• Original: J:143124 Kim I, et al., Polycystin-2 expression is regulated by a PC2-binding domain in the intracellular portion of fibrocystin. J Biol Chem. 2008 Nov 14;283(46):31559-66
• All: 5 reference(s)