Phenotypes for Htr2c Mc4r MGI:3823073 MGI Mouse

About Help FAQ

Phenotypes Associated with This Genotype

Allelic Composition	Htr2c^tm1Knk/Y Mc4r^tm1Lowl/Mc4r^tm1Lowl
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htr2c^tm1Knk mutation (1 available); any Htr2c mutation (16 available)
Mc4r^tm1Lowl mutation (2 available); any Mc4r mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

polyphagia ( J:142503 )

• mice exhibit hyperphagia

growth/size/body

growth/size/body region phenotype ( J:142503 )

N	• unlike when either gene is knocked-out, mice exhibit normal growth rates

decreased body mass index ( J:142503 )

• at 6 weeks but not 16 weeks

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/30/2025 MGI 6.24