Phenotypes Associated with This Genotype

Genotype
MGI:3822810

• Allelic Composition: Stk4^{Gt(AJ0315)Wtsi}/Stk4^{Gt(AJ0315)Wtsi}
• Genetic Background: B6.129P2-Stk4^{Gt(AJ0315)Wtsi}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased T cell apoptosis ( J:142674 )

• in vivo, nave and effector T cells have an apoptosis rate that is twice that of controls

• effector T cells also have an increased rate in apoptosis in vitro after stimulation, though nave T cells have a decreased rate of apoptosis in vitro

increased T cell proliferation ( J:142674 )

• naive T cells proliferate two- to five- fold greater in response to anti-CD3 while memory and effector T cells proliferate at a rate similar to controls

abnormal T cell differentiation ( J:142674 )

• there is a marked reduction in the number of T cells displaying the CD62L^hi/CD44^lo/ nave phenotype in the spleen, lymph nodes and circulation

• numbers of effector/memory T cells are similar or slightly increased in the secondary lymph node tissues compared to controls

• an increase in the number of CD4⁺ effector cells is observed in the lung

decreased CD4-positive, alpha-beta T cell number ( J:142674 )

• the percent and absolute numbers of CD4⁺ T cells in the blood are reduced by a half to two-thirds

• CD4⁺ T cell numbers are also reduced in the spleen

decreased CD8-positive, alpha-beta T cell number ( J:142674 )

• the percent and absolute numbers of CD8⁺ T cells in the blood are reduced by a half to two-thirds

• CD8⁺ T cell numbers are also reduced in the spleen

abnormal memory T cell number ( J:142674 )

• numbers of effector/memory T cells are similar or slightly increased in the secondary lymph node tissues compared to controls

decreased spleen white pulp amount ( J:142674 )

• the amount of white pulp is reduced

increased interferon-gamma secretion ( J:142674 )

• nave and effector CD4⁺ T cells have enhanced production of IFN-gamma in response to anti-CD3 stimulation

increased interleukin-2 secretion ( J:142674 )

• nave and effector CD4⁺ T cells have enhanced production of IL-2 in response to anti-CD3 stimulation

increased interleukin-4 secretion ( J:142674 )

• nave and effector CD4⁺ T cells have enhanced production of IL-4 in response to anti-CD3 stimulation

hematopoietic system

increased T cell apoptosis ( J:142674 )

• in vivo, nave and effector T cells have an apoptosis rate that is twice that of controls

• effector T cells also have an increased rate in apoptosis in vitro after stimulation, though nave T cells have a decreased rate of apoptosis in vitro

increased T cell proliferation ( J:142674 )

• naive T cells proliferate two- to five- fold greater in response to anti-CD3 while memory and effector T cells proliferate at a rate similar to controls

abnormal T cell differentiation ( J:142674 )

• there is a marked reduction in the number of T cells displaying the CD62L^hi/CD44^lo/ nave phenotype in the spleen, lymph nodes and circulation

• numbers of effector/memory T cells are similar or slightly increased in the secondary lymph node tissues compared to controls

• an increase in the number of CD4⁺ effector cells is observed in the lung

decreased CD4-positive, alpha-beta T cell number ( J:142674 )

• the percent and absolute numbers of CD4⁺ T cells in the blood are reduced by a half to two-thirds

• CD4⁺ T cell numbers are also reduced in the spleen

decreased CD8-positive, alpha-beta T cell number ( J:142674 )

• the percent and absolute numbers of CD8⁺ T cells in the blood are reduced by a half to two-thirds

• CD8⁺ T cell numbers are also reduced in the spleen

abnormal memory T cell number ( J:142674 )

• numbers of effector/memory T cells are similar or slightly increased in the secondary lymph node tissues compared to controls

decreased spleen white pulp amount ( J:142674 )

• the amount of white pulp is reduced

cellular

increased T cell apoptosis ( J:142674 )

• in vivo, nave and effector T cells have an apoptosis rate that is twice that of controls

• effector T cells also have an increased rate in apoptosis in vitro after stimulation, though nave T cells have a decreased rate of apoptosis in vitro

increased T cell proliferation ( J:142674 )

• naive T cells proliferate two- to five- fold greater in response to anti-CD3 while memory and effector T cells proliferate at a rate similar to controls