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Phenotypes Associated with This Genotype
Genotype
MGI:3822769
Allelic
Composition		 Gt(ROSA)26Sortm1(Hesx1)Jpmb/Gt(ROSA)26Sor+
Hesx1tm1(cre)Jpmb/Hesx1tm1(cre)Jpmb
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Hesx1)Jpmb mutation (0 available); any Gt(ROSA)26Sor mutation (1083 available)
Hesx1tm1(cre)Jpmb mutation (0 available); any Hesx1 mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:135132 )
• mice surviving to weaning age are reduced in number when compared to expected numbers

vision/eye
abnormal eye morphology ( J:135132 )
• all mutants surviving to weaninig age display eye defects

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory