About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3822318
Allelic
Composition
Leprtm2Yli/Leprtm2Yli
Genetic
Background
B6.129-Leprtm2Yli
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Leprtm2Yli mutation (0 available); any Lepr mutation (64 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• increase in body weight is less than that in Lepr db mice
• early onset obesity beginning about 4 weeks of age
• rate of weight gain begins to decline after 6 weeks of age compared to mice homozygous for Lepr db
• increase in snout to anus length compared to wild-type mice and mice homozygous for Lepr db

adipose tissue
• fat content is increased compared to wild-type mice but decreased compared to mice homozygous for Lepr tm1Yli or Lepr db
• at 8 weeks and 28 weeks of age body fat content in males is 7 fold and 2 fold higher, respectively, compared to wild-type controls

homeostasis/metabolism
• thermoregulation in response to cold exposure is slightly but significantly impaired compared to wild-type controls but improved compared to mice homozygous for Lepr db
• fasting serum glucose levels are significantly lower than those in mice homozygous for Lepr db
• increased levels relative to wild-type controls but decreased levels compared to mice homozygous for Lepr tm1Yli or Lepr db
• relatively modest hyperleptinemia compared to mice homozygous for Lepr db
• increased compared to mice homozygous for Lepr db but not significantly different from wild-type controls
• oxygen consumption normalized to lean mass is similar to wild-type controls but decreased relative to mice homozygous for Lepr db
• oxygen consumption normalized to metabolic size is decreased by about 20% compared to wild-type controls but is still higher than in mice homozygous for Lepr db
• impaired compared to wild-type controls but not as bad as in mice homozygous for Lepr tm1Yli or Lepr db
• resistant compared to wild-type controls but more sensitive compared to mice homozygous for Lepr tm1Yli or Lepr db

behavior/neurological
• hyperphagia is less pronounced compared to mice homozygous for Lepr db
• activity levels in both dark and light cycles are decreased compared to wild -type controls but increased compared to mice homozygous for Lepr db

reproductive system
• fertility is about 40% that of wild-type controls

Mouse Models of Human Disease
OMIM ID Ref(s)
Obesity 601665 J:142218


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/19/2016
MGI 6.04
The Jackson Laboratory