Phenotypes Associated with This Genotype

Genotype
MGI:3822162

• Allelic Composition: Mapk3^tm1Gpg/Mapk3^tm1Gpg; Tg(CAG-cat,-Ptpn11*Q97R)1Rbns/0; Tg(Tek-cre)12Flv/0
• Genetic Background: involves: 129/Sv * C3H * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:142212 )

• all mice died by E14.5

• however, Mendelian ratios of embryos are present at E13.5

cardiovascular system

cardiovascular system phenotype ( J:142212 )

N • mice exhibit normal endocardial cushion size and rates of proliferation and apoptosis of endothelial and mesenchymal cushion cells

liver/biliary system

hepatic necrosis ( J:142212 )

homeostasis/metabolism

nuchal edema ( J:142212 )

• mice exhibit nuchal edema

integument

nuchal edema ( J:142212 )

• mice exhibit nuchal edema

growth/size/body

nuchal edema ( J:142212 )

• mice exhibit nuchal edema